Inhibition of platelet aggregation by clopidogrel is solely due to an Lively metabolite. Clopidogrel is metabolized to this Energetic metabolite partly by CYP2C19. .
cyclophosphamide will raise the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.
Read all client info, medication guides, and instruction sheets presented for you. Talk to your physician or pharmacist In case you have any issues.
stiripentol will boost the level or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Look at minimizing the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
Working with Alcoholic beverages or tobacco with specific medicines might also induce interactions to arise. Go over along with your Health care Specialist using your medication with meals, alcohol, or tobacco.
Possession of some modafinil capsules can lead to three to 10 a long time imprisonment. Modafinil is not accredited for healthcare use in Russia and cannot be bought even in pharmacies. Additionally, it can't be imported from overseas, even When you have a prescription issued exterior Russia.[197][208] There are actually several situations of prison proceedings initiated versus Russian people who tried to import modafinil by mail from overseas.[209][210]
anastrozole will improve the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.
Caffeine, a methylxantine by-product, has actually been utilized being a psychoactive drug for a protracted period of time. For healthier Grownups, the halflife of caffeine is five hrs and it might be extended approximately 11 hrs for pregnant Ladies or women getting beginning Manage drugs [26]. Caffeine functions as an antagonist of adenosin receptors [27,28]. Pharmaceutically, caffeine is actually a stimulant of metabolism plus the central nervous method but more info is also utilised as being a Way of living drug as well as a scientific drug to reduce Bodily fatigue and retain alertness.
As talked about while in the past sections to the biological mechanisms of modafinil, this drug’s interactions with the dopamine transporter are considered “atypical,” and won't create many of the psychological results that bring about folks to abuse it (like euphoria
A 2020 assessment noted that modafinil features a modest effect on memory updating, though the impact is smaller and could not properly replicate the notion that it is useful as being a cognitive enhancer, as You can find inadequate proof to support this kind of assert.[264]
Modafinil is utilised to treat too much sleepiness a result of rest apnea, narcolepsy, or change perform slumber problem.
No enough reports in people have investigated the security of modafinil use in the course of pregnancy. Hence, warning is suggested, and using modafinil through pregnancy is normally only accredited if a professional health care Experienced has a selected motive to feel that the opportunity therapeutic benefits outweigh the potential dangers [38].
As outlined by several scientific tests in cells and animals, modafinil has long been claimed to point out synergistic steps when combined with SSRIs (
To maintain from receiving pregnant, use One more type of birth Regulate while you are applying this medicine and for 1 month after your previous dose. Other forms of beginning Manage include condoms, diaphragms, or contraceptive foams or jellies.